Archive for February, 2008

Daily asthma meds keep lungs in play during exercise

NEW YORK (Reuters Health) - Taking asthma medication daily can help prevent the tightening of the airways or "bronchoconstriction" with physical exertion that affects many children with asthma, a new study from Poland confirms.

Dr. Iwona Stelmach of N. Copernicus Hospital in Lodz and colleagues found that of the four treatments they evaluated, the two including the anti-asthma drug montelukast (Singulair) were the most effective, but all were better than placebo.

"Control of childhood asthma with exercise-induced bronchoconstriction can be obtained by using regular controller treatment," Stelmach and colleagues write in the Journal of Allergy and Clinical Immunology.

Children may often forget to take bronchodilators before exercising, the researchers note, but daily medications can also help make airways less hyperresponsive to exertion, and don't have to be taken right before children exercise.

The researchers compared the effectiveness of four different daily treatment approaches: budesonide (Pulmicort turboinhlaer) and formoterol (Oxis turboinhaler); budesonide and montelukast; montelukast alone; and budesonide alone.

They randomized 100 children with exercise-induced bronchoconstriction to one of the treatments or placebo for four weeks. All of the children had a treadmill exercise test before and after treatment.

All children who received active asthma treatment showed a significant reduction in exercise-induced airway tightening, but improvements were greatest in the montelukast-only and montelukast-plus-budesonide groups.

There was no difference between the two montelukast groups, suggesting that budesonide didn't have an additional effect. However, the researchers say, this could have been because the study was too small to detect the difference.

"It can be argued that adding montelukast should be recommended to achieve better control of exercise-induced bronchoconstriction in children with asthma," they conclude.

SOURCE: Journal of Allergy and Clinical Immunology, February 2008.

Copyright © 2008 Reuters Limited.

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ER of future fights threats big and small

WASHINGTON (Reuters) - Like every U.S. hospital emergency room, the one at Washington Hospital Center is overwhelmed -- on any day patients lie on gurneys in the corridor, hooked up to monitors. Others wait for hours to see a doctor.

But next door to the old and crowded emergency department is a bright oasis of calm. Backed by a $2.2 million federal grant and drawing on 600 different ideas from a task force of experts, the hospital is putting in what emergency department chairman Dr. Mark Smith hopes will be a first draft of the emergency department of the future.

It is designed to handle a sudden influx of mass casualties from a natural disaster, biological attack or a pandemic, and at the same time prevent the ongoing disaster of hospital-acquired infections.

"Our goal is to build a center as a demonstration facility -- a model test bed for the rest of the country," Smith said in an interview.

"The risk of terrorism is real. The likely targets are going to be New York City and Washington."

On September 11, 2001, all the people injured in the Pentagon when a hijacked jet crashed through its walls were treated at Washington Hospital Center, the largest trauma center in the area and the region's specialty burn center.

"We recognized that we have a very, very special responsibility. We are a national security asset," Smith said as he gave a tour of the unfinished section. The hospital is owned by nonprofit MedStar Health.

The new facility must work as an emergency room day-to-day, but must quickly accommodate three to five times the usual number of patients. It must resist an invasion of germs from inside, and withstand attacks from the outside.

SURGE CAPACITY

More than 115 million people visited emergency rooms across the United States in 2005, according to the U.S. Centers for Disease Control and Prevention -- a 20 percent increase over the previous decade.

But between 1995 and 2005, the number of ERs dropped by 9 percent, from 3,795 from 4,176.

Several reports show there is no surge capacity in U.S. hospitals, and predict that even a bad flu season, let alone a pandemic of avian influenza, will completely overwhelm them.

With 10 new patient bays and two movable nurses' stations, this new ER will fill an immediate need, as well as having a built-in capacity to deal with surges.

Unlike most emergency department treatment bays, which are usually barely larger than a closet, these are spacious and airy. Each has three beds, but in daily use a patient will ideally be alone.

Sliding glass doors can convert each bay into a sealed isolation unit, with negative pressure systems to keep infections from spreading, and outfitted with a hydrogen peroxide gas disinfection system.

The doors can rotate out to make the bay fit two more beds, accommodating five patients at once, although not under sealed conditions.

That means this section of the emergency department can accommodate 50 patients without anyone being in a corridor.

The air pumped into and out of the rooms can be filtered and sterilized using ultraviolet light. A typical 30-bed emergency department has two negative pressure rooms. This one will have 10, Smith said.

"What is going to work for smallpox and plague is going to work for pandemic flu," Smith said.

The air comes in from above, flows across the patient beds and is sucked out near ground level in a corner, to protect staff by swooping germs away from them.

A typical hospital room has eight to 10 air changes an hour. These fill with fresh air 15 to 18 times an hour and can be ramped up to 25 exchanges an hour under negative pressure conditions to foil airborne viruses and bacteria.

Such measures can be used when patients are being treated for highly infectious respiratory diseases such as severe acute respiratory syndrome, which infected 8,000 people globally and killed 800 after it emerged suddenly in China in 2003.

Many casualties were hospital workers.

SECOND FRONT

But a second experiment is under way at the same time.

"Hospitals haven't improved infection control," says Ella Franklin, a registered nurse with a degree in public health who is the project manager.

The CDC reports that staphylococcus and other bugs that thrive in hospitals kill 90,000 people a year at a cost of $4.5 billion.

Franklin has turned the new ER into an experiment testing design, procedures and new materials to see if they can do better.

"We have the knowledge in other industries and we haven't done it in healthcare," she said. "We know from the food industry that a non-porous Corian surface doesn't support microbial growth."

She runs her hand along a blue-green strip of Corian, made by DuPont Co, just above waist level on the wall. "This is where people will put their hands to steady themselves," she said.

Every time a hand touches a wall, germs can transfer and the oils on a human hand help them stick. They can burrow into tiny crevices and create biofilms -- living colonies than are maddeningly hard to eradicate.

"I can tell my environmental services staff 'make sure you get this strip' because we know that is where people put their hands," Franklin said.

Control panels on the monitors in the rooms will be coated with a clear plastic antimicrobial film.

Franklin hopes each room will be cleaned at least daily and optimally between patients, but years of experience have told her this often does not happen in a busy emergency department.

Silver ion technology from Massachusetts-based Agion Technologies Inc. has been used to make door frames and handles.

"I will be doing microbial swabbing to make sure this works," Franklin said.

Acoustic tiles will absorb noise as part of an experiment to see if quieter working conditions help prevent the distractions that cause harried workers to make mistakes.

Sinks are right by the door and will be fitted with sensors, so that they are lit up as someone walks by to entice staffers to wash their hands as they enter and exit.

"We have seen in the military, we have seen in aerospace engineering, that you can design a space to lead a person to do the right thing," Franklin said.

Computer keyboards pose a special challenge. "Like everyone else's keyboards, they are contaminated." A keyboard designed to survive dunking in a bleach solution did not work well, so Franklin is trying an antimicrobial shrink-wrap cover instead.

Copyright © 2008 Reuters Limited.

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CT scans lower risk of unnecessary appendix surgery

BOSTON (Reuters) - The chance of having an appendix removed unnecessarily has plummeted since 1996 in the United States, possibly because more doctors are using CT scans to confirm appendicitis diagnoses, researchers said on Wednesday.

The likelihood of an unnecessary appendectomy went from 24 percent in 1996 down to 3 percent in 2006, according to a team of researchers led by Dr. Steven Raman at the University of California, Los Angeles.

Their survey of 1,081 people who had had an appendix removed showed the use of CT scans to check for suspected appendicitis went from 20 percent in 1996 to 85 percent 10 years later.

About 8 percent of the population develops appendicitis at some point in their lives as the finger-like sac at the start of the large intestine becomes enlarged and inflamed.

If the sac bursts, it can be fatal. Doctors have historically erred on the side of surgery when it looked like a patient with abdominal pain might have appendicitis.

The results appear in a letter to the New England Journal of Medicine.

Copyright © 2008 Reuters Limited.

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What a nightmare: Americans get too little sleep

WASHINGTON (Reuters) - With late-night TV watching, Internet surfing and other distractions, Americans are getting less and less sleep, the U.S. Centers for Disease Control and Prevention said on Thursday.

And all this sleeplessness can be a nightmare for your mental and physical health, CDC experts cautioned, calling sleep loss an under-recognized public health problem.

Sleep experts say chronic sleep loss is associated with obesity, diabetes, high blood pressure, stroke, cardiovascular disease, depression, cigarette smoking and excessive drinking.

The CDC surveyed 19,589 adults in four states. Ten percent reported they did not get enough sleep or rest every single day of the prior month, and 38 percent said they did not get enough in seven or more days in the prior month.

The CDC survey was conducted in New York, Hawaii, Delaware and Rhode Island, asking people how many days in the prior month they got insufficient rest or sleep, without asking specifically how many hours they slept.

But the CDC released nationwide data collected separately showing that across all age groups, the percentage of adults reporting sleeping six hours or less a night increased from 1985 to 2006.

The National Sleep Foundation recommends adults get seven to nine hours of sleep a night. Children ages 5 to 12 should get nine to 11 hours and those 11 to 17 need 8-1/2 to 9-1/2 hours.

SLEEP IS VITAL

"At night, we're doing everything except for sleeping -- we're on the Internet, we may be watching TV. With these new lifestyles we have kind of taken sleep for granted as something that we can do when we have time or we can catch up on it on the weekends," CDC behavioral scientist Lela McKnight-Eily, who led the study, said in a telephone interview.

"We don't realize that sleep is a vital part of overall health and that chronic sleep loss is related to both physical and mental health issues," she added. "It's getting worse."

Darrel Drobnich, National Sleep Foundation chief executive officer, added that several thousand people die on U.S. roads yearly in accidents involving drowsy drivers.

"Americans are definitely sleep deprived. They don't get the amount that even they say that they want," Drobnich said.

The CDC said 50 to 70 million Americans suffer from chronic sleep loss and sleep disorders in a country of 300 million.

The CDC four-state survey found that younger adults are more likely than older adults to report getting too little sleep. It also found overall that 30 percent of respondents said they got enough sleep every day of the past month, and 33 percent got too little on one to six days in the prior month.

Lela McKnight-Eily urged people who often get too little sleep to see a doctor to see whether lifestyle issues are to blame or whether they might have a sleeping disorder. People can also try to establish a regular sleep schedule and avoid caffeine or other stimulants before bedtime, she added.

Copyright © 2008 Reuters Limited.

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Stem cell transplant boosts breast cancer risk

NEW YORK (Reuters Health) - Female cancer survivors who have been treated with a type of stem cell therapy called hematopoietic cell transplantation, or HCT, have an increased long-term risk of developing breast cancer, according to US and European researchers.

Lead investigator Dr. Debra L. Friedman told Reuters Health that HCT is being used with "greater success to treat a number of malignancies as well as non-malignant conditions. It is essential for long-term survivors and their health care providers to understand the potential adverse long-term outcomes associated with this therapy."

Among a group of 3,337 women who had HCT and survived for at least 5 years, Friedman, of the Fred Hutchinson Cancer Research Center, Seattle, and colleagues found that 52 developed breast cancer after a median of 12.5 years.

The 25-year cumulative incidence of breast cancer was 11 percent. The incidence of breast cancer was significantly higher in survivors who received total body irradiation (17 percent) than in those who did not (3 percent).

The longer since HCT, the greater the breast cancer risk.

Results also showed the use of total body irradiation prompted a fourfold greater risk of breast cancer and being 18 years old or younger at the time of HCT carried a hazard ratio of 9.5.

Breast cancer after HCT is a potential adverse outcome, noted Friedman, "and thus it is important for women at risk to undergo regular screening...to facilitate early detection."

"More research," she concluded, "is required to better understand other risk factors for breast cancer in these survivors."

SOURCE: Blood, January 15, 2008.

Copyright © 2008 Reuters Limited.

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